Structure determination of 10,000 properly chosen proteins should result in useful three-dimensional models for hundreds of thousands of other protein sequences. In other words, structural ...

These observations challenge traditional thinking concerning the specific three-dimensional structure of proteins and their function. Clearly we can no longer ignore the role of disorder in ...

This article was originally published with the title “ The Three-Dimensional Structure of a Protein Molecule ” in Scientific American Magazine Vol. 205 No. 6 (December 1961), p. 96 doi:10.1038 ...

so different proteins have different three-dimensional shapes. The three-dimensional shape of a protein determines its function. This is because proteins form attachments and interact with many ...

Protein folding has been an ongoing problem for researchers since 1972. Christian Anfinsen speculated in his Nobel Prize acceptance speech in that year that the three-dimensional structure of a ...

Determining a protein’s three-dimensional structure based solely on its one-dimensional amino acid sequence has stood as a grand challenge in the field of biology for over half a century.

AlphaFold solved a structural biology riddle: predicting protein structure. And yet, CASP, a global competition born to solve ...

Proteins are composed of one or more chains of amino acids, which are linked together by peptide bonds and folded into specific three-dimensional structures. Proteins have four levels of structure: ...

Based on a protein’s three-dimensional surface structure, the algorithm designs molecules that bind specifically to the protein according to the lock- and-key principle, so they can interact ...

"The whole way in which a protein functions is dependent on its three-dimensional structure and protein function is relevant to everything in health and disease. "By knowing the three-dimensional ...

The protein’s three-dimensional shape is thus determined ... But you can also have a draft of a structure that you feed into ...