The genetic connections between DNA repair pathways and human cancer predisposition have fueled interest ... 3’ dideoxy and 5’-phosphate termini but cannot catalyze adenylation of the 5’-end. Thus, ...

Several cancer chemotherapy drugs work by producing excessive DNA damage that causes cell death directly or following DNA replication. Survival is promoted through repair of these lesions by a ...

If DNA damage is not properly repaired, mutations can occur, which may result in diseases like cancer. Cells use repair systems to fix this damage, with specialized proteins locating and binding ...