The so-called tumor microenvironment (TME ... has come up with a range of TME-related targets, like TGF-β, Notch, etc., supporting cancer treatment and accelerating the R&D procedure of users.

The tumor microenvironment (TME) consists of various components, including cancer cells ... each other via various cytokines including TGF-β and TNF-α, which often induce tumor progression.

In its two lead cancer assets ... In 2018, researchers found TGF-β, which is elevated in the tumor microenvironment, reduces the ability of T cells to penetrate tumors, thereby reducing the ...

Its malfunctions cause developmental defects, immune disorders, fibrosis, and cancer. We defined a pathway in which TGF-β binds to receptor serine ... mesenchymal cells and immune cells in the tumor ...

3- Kindlin-2 as a major regulator of the oncogenic signaling of TGF-β and cancer cell senescence: We also established Kindlin-2 as a major player in the modulation of the tumor microenvironment by ...

Cancer Sci. 112, 3796-3809 (2021). doi: 10.1111/cas.15034. 5. Kubota SI, Takahashi K, Mano T, Matsumoto K, Katsumata T, Shi S, Tainaka K, Ueda HR, Ehata S, and Miyazono K. "Whole-organ analysis of TGF ...

ficerafusp alfa has the potential to exert potent anti-tumor activity by simultaneously blocking both cancer cell-intrinsic EGFR survival and proliferation, as well as the immunosuppressive TGF-β ...

A live webcast of the presentation will be available on the Events and Presentations section of Bicara’s website at www.bicara.com. An archived replay of the webcast will be available for ...

Adicet Bio, Inc. (Nasdaq: ACET), a clinical stage biotechnology company discovering and developing allogeneic gamma delta T ...

Through this dual-targeting mechanism, ficerafusp alfa has the potential to exert potent anti-tumor activity by simultaneously blocking both cancer ... TGF-β signaling within the tumor ...