The tumor microenvironment (TME) consists of various components, including cancer cells ... each other via various cytokines including TGF-β and TNF-α, which often induce tumor progression.

The so-called tumor microenvironment (TME ... has come up with a range of TME-related targets, like TGF-β, Notch, etc., supporting cancer treatment and accelerating the R&D procedure of users.

In its two lead cancer assets ... In 2018, researchers found TGF-β, which is elevated in the tumor microenvironment, reduces the ability of T cells to penetrate tumors, thereby reducing the ...

Its malfunctions cause developmental defects, immune disorders, fibrosis, and cancer. We defined a pathway in which TGF-β binds to receptor serine/threonine kinases that ... mesenchymal cells and ...

3- Kindlin-2 as a major regulator of the oncogenic signaling of TGF-β and cancer cell senescence: We also established Kindlin-2 as a major player in the modulation of the tumor microenvironment by ...

Through this dual-targeting mechanism, ficerafusp alfa has the potential to exert potent anti-tumor activity by simultaneously blocking both cancer cell-intrinsic EGFR survival and proliferation, as ...

BOSTON, Nov. 11, 2024 (GLOBE NEWSWIRE) -- (Nasdaq: BCAX), a clinical-stage biopharmaceutical company committed to bringing transformative bifunctional therapies for patients with solid tumors, today ...

Adicet Bio, Inc. (Nasdaq: ACET), a clinical stage biotechnology company discovering and developing allogeneic gamma delta T ...