Tumor cells transform fibroblasts into cancer-associated fibroblasts, which have an important immunosuppressive activity on which growth, invasion, and metastasis depend. These activated fibroblasts ...

Given the vital role of such cellular crosstalk interactions in regulating tissue homeostasis and repair, it had been speculated that dysregulated stromal-immune communication is a key pathogenic ...

Tissue vaccines include antigens associated with neoplastic cells and with the tumor stroma. Furthermore, they include antigens that may be expressed only following in vivo growth versus growth in ...

Here are some soft-tissue sarcomas of the abdomen: Gastrointestinal stromal tumor (GIST) usually forms in the stomach or small intestine. Leiomyosarcoma most commonly forms in the uterus. It can also ...

Invasive cells with these protrusions expand out in to the surrounding tissue stroma (arrows). The green structure on the top of the movie frame is the kidney duct. The intestine is below the ...