Cell 153, 1094-1107. STING Activation by cGAMP. cGAMP has been shown by the Zhijian Chen lab to bind the signaling protein STING with subsequent activation of the IFN pathway. Our structural studies ...

The cGAS–STING pathway is a component of the innate immune system that functions to detect the ... Upon recognition of a PAMP, PRRs generate signal cascades leading to transcription of genes ...

Published this week in Cell Reports Medicine, the study reveals that the drug lurbinectedin, an approved second-line therapy for SCLC, activates the STING-IFN signaling pathway to enhance the ...

A study published in the journal Molecular Cell has shed light on the multifaceted role of STING, a protein previously ...