Double-edged STING: A new pathway involved in aging
A protein called STING, previously shown to control a pathway that contributes to antiviral signaling, also plays an ...
EurekAlert!6 个月
The cGAS-STING pathway facilitates crosstalk between cancer cells and the tumor ...
The cGAS-STING pathway facilitates crosstalk between cancer cells and the tumor microenvironment (TME). The activation of cGAS-STING promotes the release and presentation of cancer antigens ...
Nanowerk3 年
cGAS–STING cytosolic DNA sensing pathway
The cGAS–STING pathway is a component of the innate immune system that functions to detect the ... Upon recognition of a PAMP, PRRs generate signal cascades leading to transcription of genes ...
EurekAlert!8 个月
cGAS-STING pathway response model for micronucleus (IMAGE)
An artist's impression of cGAS-STING pathway response model for micronucleus. Before, cGAS's accumulation in micronuclei was considered to be an indicator of cGAS activation. Now, it was found ...
Protein signaling pathway provides insights into cell migration and cancer metastasis
However, our data suggest that 2'3'-cGAMP could also activate Rab18/FosB signaling pathway—but not the well-studied ...