We are also actively investigating the regulation of Syk tyrosine kinase binding to membrane immune receptors and other signaling proteins. Syk recognizes doubly phosphorylated regions of the receptor ...

tyrosine kinase REarranged during Transfection (RET), but GFLs can activate RET only in the presence of a co-receptor—GDNF Family Receptor α (GFRα). Specificity arises through the preferential binding ...

AKT signaling pathway is one of the most critical and extensively investigated signaling pathways. It is the central ...

A central question in adult stem cell biology is elucidating the signaling pathways regulating their dynamics and function in diverse physiological and age-related contexts. Muscle stem cells in ...

Gao Guo is an assistant professor in the UAB Department of Neurosurgery. His research focuses on elucidating the role of receptor tyrosine kinase in the invasion and survival of glioblastoma (GBM). He ...

Key proteins, such as suppressor of cytokine signaling (SOCS3) and protein-tyrosine phosphatase 1B (PTP1B), inhibit ... When ...

This work is an important contribution to understanding the role of FGF signaling in the induction of primitive-like cells in a 2D system of human gastrulation. The authors provide compelling evidence ...

InnoCare Pharma (HKEX: 09969; SSE: 688428), a leading biopharmaceutical company focusing on the treatment of cancer and autoimmune diseases, today ann ...

Data demonstrate potential superiority of a targeted protein degradation strategy compared to kinase inhibition for both BTK ...