PBC patients receiving linerixibat saw statistically significant improvement in cholestatic pruritus - or relentless itch.

Published reports on placebo-controlled clinical trials and other studies investigating the use of pure opioid antagonists for the prevention and treatment of opioid-induced pruritus (OIP ...

The itching may or may not come along with a rash, which can be limited to small areas of skin or can occur over the entire ...

Itching (pruritus) is one symptom of chronic liver disease, though not everyone with liver disease develops it. You might have a localized itch, such as on your lower arm, or it might be an all ...

Treatment with dupilumab is safe and effective for patients with bullous pemphigoid, with complete remission seen as early as 4 weeks of treatment.

Treatment with liberixibat led to a statistically significant improvement in itch compared with placebo. Topline results were announced from a phase 3 trial evaluating linerixibat for the ...

On examination of the colony, severely affected guinea pigs showed intense pruritus, widespread alopecia, and greasy skin with self-inflicted sores. Based on the history and clinical signs ...

"We look forward to initiating a Phase 2 multiple-ascending dose trial in the coming months to evaluate TH104 in chronic pruritus in primary biliary cholangitis (PBC) patients, with topline data ...

GSK’s linerixibat has shown promising results in a late-stage trial of primary biliary cholangitis (PBC) patients with ...

In the three aforementioned studies of epidural delivery of naloxone in combination with an opioid (fentanyl or morphine), the frequency of pruritus was decreased, with no reversal of analgesia noted.

Cholestatic pruritus is a common symptom of primary biliary cholangitis (PBC), a rare autoimmune liver disease. Researchers are looking to establish the safety and efficacy of linerixibat – an ...