and an understanding of how protein kinases function in vivo is therefore of central importance to cell biology. Newly developed protein-kinase inhibitors provide powerful tools for understanding ...

Cyclin-dependent kinases (CDKs) are protein kinases involved in critical ... on the basis of similarities in sequence and function as described below. This nomenclature will facilitate the ...

The molecular basis of phospho-tyrosyl-regulation of Src-family and Syk-family protein tyrosine kinases in signaling pathways is a current focus of the lab. The conformational activation of Src kinase ...

Protein tyrosine kinases and protein tyrosine phosphatases coordinate to maintain a protein phospohorylation balance required for normal cell function. If this balance is disrupted, the outcome may be ...

A new approach to targeting a protein involved in cell division, which can misfunction in cancer, has revealed new insights ...

WNKs sense osmotic pressure by binding specific water molecules to the inactive dimeric configuration of WNK1 and WNK3, integrating signals with chloride inhibition as demonstrated by mutagenesis and ...

A research group of The University of Tokyo has discovered that in mammals, a protein kinase A (PKA) promotes wakefulness, ...