p53 is a common denominator among human cancers. How was it discovered? What are the persistent questions about its function? Aa Aa Aa It seems nearly impossible for a normal cell to become a ...

One can use the p53 and Mdm2 families of proteins ... Unlike the chaperones that induce a fixed three-dimensional structure to the client proteins, nanny activity is transient, and the induced ...

The fragile structure of p53 gene reveals why this crucial cancer defense is so easily compromised ... which leads to p53 inactivation in many cancers. TP53 is the gene that encodes the p53 protein.

Through studies of proteins that regulate p53, scientists at St ... with nucleophosmin but also assembling a large network structure that had some symmetry," explained Gibbs.