Nanobody extravasation & tumor penetration Due to elevated interstitial pressure, penetration of therapeutics into the tumor is mediated by diffusion. As this depends on size, nanobodies in ...

Sufficient tumor accumulation therefore requires a sufficient residence time of the nanobody in the blood stream, which differs for the type of nanobody platform. Naked nanobodies are rapidly ...

A new research paper was published in Oncotarget titled, "A nanobody against the V-ATPase c subunit inhibits metastasis of ...

Third, Poseidon’s TCEs have multiple binding modalities to enhance tumor selectivity and address heterogeneous antigen expression. Poseidon can introduce multiple copies of the same nanobody to ...

They engineered a CD13-binding nanobody (aCD13Nb) that strongly interacts with CD13, in addition to attaching Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL), a protein known to ...

Utilizing the phage antibody library approach, Sino Biological has independently built a platform for the production of nanobodies and has produced numerous successful nanobody candidates.

In their report, titled “Adaptive multi-epitope targeting and avidity-enhanced nanobody platform for ultrapotent, durable antiviral therapy,” the researchers commented, “Altogether ...

More information: Jun Yu et al, Structural basis of μ-opioid receptor targeting by a nanobody antagonist, Nature ...

The initiation of this Phase 3 program follows the announcement in June 2024 of the successful outcome of MoonLake’s end-of-Phase 2 interactions with the U.S. Food and Drug Administration (FDA), as ...

An example of the Virtual Lab in action is its application to nanobody design for combating the SARS-CoV-2 virus. The PI agent assembles a team (e.g., immunologist, machine learning specialist ...