This important work substantially advances our understanding of reactive oxygen species (ROS) as a regenerative signal during postnatal cerebellum repair by activating adaptive progenitor ...

Low-oxygen levels ... based on inflammatory microenvironment modulation for improved response rate. Ultimately, we aim to reverse the progression of cancer both in terms of staging and operability.

Immune checkpoint blockades, or ICBs, have revolutionized treatment for various advanced cancers. However, their ...

HIF1α identified as key regulator that induces cancer-killing ability of hypoxic T cells, playing a role in ICB resistance.

The regulator HIF1α functions in a cancer-microenvironment that lacks oxygen, and it may be involved in resistance to immune checkpoint ... Shi and colleagues showed this key role for HIF1α in hypoxia ...

The regulator HIF1α functions in a cancer-microenvironment that lacks oxygen, and it may be involved ... for HIF1α in hypoxia by combining genetic mouse models, metabolic flux analysis using ...

Yet any potential intervention has to take place under unusual conditions—the cancer microenvironment nearly devoid of oxygen due to ... by combining genetic mouse models, metabolic flux ...

Our previous reports have focused on the tumor microenvironment in liver cancer ... anti-PD1 is more effective than anti-PD1 alone in mouse models of liver cancer and that the increased dendritic ...