Activated microglia may play a role in OPC and oligodendrocyte loss or replacement, but it is not clear how the responses of OPCs and oligodendrocytes to activated microglia differ. Methods ...

Scientists broadly agree that both apolipoprotein E and microglia are necessary ingredients for amyloidosis. In mice devoid of ApoE, or of their microglia, scant plaques form. Now, a sweeping study ...

We chose 10 ng/ml LPS for use in further experiments, as this dose has been shown by others to induce microglia-mediated OPC death [48] and was in the middle of our range of LPS doses that induced ...