Activated microglia may play a role in OPC and oligodendrocyte loss or replacement, but it is not clear how the responses of OPCs and oligodendrocytes to activated microglia differ. Methods ...

We chose 10 ng/ml LPS for use in further experiments, as this dose has been shown by others to induce microglia-mediated OPC death [48] and was in the middle of our range of LPS doses that induced ...