There is evidence to indicate that full adrenergic blockade by carvedilol improves survival and cardiovascular outcome in patients with heart failure compared with metoprolol treatment ...

A number of comparative studies have been performed with metoprolol, a β 1-selective "second-generation" β blocker, and carvedilol, a nonselective and vasodilatative "third-generation" β blocker.

Patients were switched if they were stable on a minimum dose of 25 mg b.i.d. carvedilol or 100 mg metoprolol. The crossover was performed within 1 day during monitoring of blood pressure and heart ...