The disparity in the results between the Metoprolol in Dilated Cardiomyopathy Trial and MERIT-HF raised the possibility that only extended- release metoprolol succinate is effective in treating ...

It should be emphasized that the metoprolol studied in COMET was the tartrate preparation, not the succinate once-daily formulation used in MERIT-HF. Additionally, the target dose of metoprolol ...