[19] This may be the other mechanism of action of Silymarin in the treatment of melasma. Silymarin inhibited l-DOPA oxidation activity of tyrosinase, the rate-limiting melanogenic enzyme ...

[11] Placebo is a cream base free from active constituent ... This is a double blind, randomized clinical study on patients with melasma attending the outpatient clinic of the Dermatology ...

Dermatologists will also tell you that the interest around tranexamic acid is entirely justified—especially because it is ...

“Wearing broad-spectrum sunscreen with an SPF of at least 30 and protective clothing can help prevent melasma from worsening.

For melasma, retinol can be used as a stand-alone topical and is also commonly prescribed as a combination cream,' says Dr. Charles. Still, some doctors may recommend you skip using it on its own ...