Thus, finding more effective treatments is a primary aim of medical researchers. Ketamine, an NMDA receptor antagonist, commonly used as an anesthetic, has attracted the attention of many researchers ...

In recent years, ketamine — long known for its misuse as a psychedelic party drug — has become a “life-saving” medicine for ...

University at Buffalo neuroscientists have identified the binding site of low-dose ketamine, providing critical insight into ...

News Releases News Topics Media Advisories University Statements How can low-dose ketamine, a ‘lifesaving’ drug for major depression, alleviate symptoms within hours? UB research reveals how   These ...

Ketamine binds to a class of neurotransmitter receptors called N-methyl-D-aspartate (NMDA) receptors. Popescu is an expert on how these receptors produce electrical signals that are essential for ...

Now ketamine, a glutamatergic NMDA receptor antagonist, may provide a mechanism that could link these pathways. Figure 1: A schematic of how ketamine may lead to an overall excitation in the cortex.

Ketamine affects several receptors and pathways in the brain and body, with one key pathway involving glutamate. As an NMDA receptor antagonist, ketamine blocks glutamate from binding to NMDA ...

7 426–437; 2008). Increased levels of glutamate have been found in the frontal cortex of patients with MDD, and the non-selective NMDA receptor antagonist ketamine has shown antidepressant ...

This information is critical to understanding not only how best to use ketamine, but also to developing similar drugs. Selective effects on NMDA receptors Ketamine binds to a class of neurotransmitter ...

Seizure disorder. Pregnancy. Nursing mothers. Caution with other NMDA antagonists (eg, amantadine, ketamine, dextromethorphan). May affect or be affected by renally-excreted drugs (eg, triamterene ...