Children are highly susceptible to tuberculosis; thus, there is need for safe and effective preventive interventions. Our objective was to evaluate the efficacy of isoniazid in prevention of ...

Subgroup analyses based on HIV infection status found a strong protective effect of INH against TB among HIV-negative children (RR = 0.55, 95% CI 0.40, 0.75 p = 0.001), but no evidence of ...

tuberculosis organisms is also highlighted in the treatment of LTBI. The present standard of care requires nine months of therapy with isoniazid to eradicate an extremely small population of cells ...

Isoniazid is a first-line medicine for tuberculosis (TB) treatment. It is a prodrug activated by the mycobacterial catalase-peroxidase enzyme KatG. However, the development of isoniazid resistance ...

For drug-susceptible TB, although the current four-drug regimen (isoniazid, rifampin, ethambutol and pyrazinamide) is effective in most cases, the treatment takes 6–9 months because the bacteria ...

For example, combining bedaquiline with another antibiotic called isoniazid appeared to prevent the development of resistance to either drug, he said. While TB is primarily a problem in developing ...

Mycobacterium tuberculosis (M. tuberculosis), the primary agent of TB, can usually be treated with a four-drug four-month regimen often involving the front-line antibiotic isoniazid. The emergence of ...

Whole genome CRISPRi screening identifies druggable vulnerabilities in an isoniazid resistant strain of Mycobacterium ...

Findings on isoniazid-resistant M. tuberculosis reveal key vulnerabilities, suggesting new avenues for treatment strategies ...

if the TB causing organism is found to be resistant to the drugs isoniazid and rifampicn, then the person is said to be suffering from MDR-TB. Extensively drug-resistant tuberculosis (XDR-TB): XDR ...