Hemophilia A and B coagulation defects ... when it gains direct access to the failed but otherwise activated intrinsic pathway complex, or when it finds any available TF at sites of cellular ...

While nanoparticle interactions with various constituents of the immune system have been reviewed before, little attention was given to nanoparticle effects on the blood coagulation system.

Production begins when tissue factor in the extrinsic coagulation pathway is exposed in a blood vessel ... Factor IXa then moves into the intrinsic pathway and combines with factor VIIIa and ...