Medscape3d
Thyroid Autoantibodies (TPOAb, TgAb and TRAb)
Thyroid Peroxidase (TPO) is a 110 kD membrane bound hemo-glycoprotein with a large extracellular domain, and a short transmembrane and intracellular domain. TPO is involved in thyroid hormone ...
Nature3y
GPCRs are membrane-bound proteins that have seven membrane-spanning domains connected by intracellular and extracellular domains.
In the inactive conformation, the a-subunit of the G protein binds to GDP and is bound to a beta-gamma complex (a). Upon receptor activation by its ligand, there is an exchange of GDP for GTP (b).