Such feed-forward loops, however, create special opportunities for therapy. The type I interferon (IFN) system constitutes a highly redundant group of cytokines that are of critical importance to ...

Aberrations of the IFN system are also emerging as important ... Figure 2: Different interferon (IFN) signalling pathways activated by dsRNA and viruses.

In individuals with a compromised type 1 interferon system, severe viral infections can occur because the body cannot mount a full defense. Recent research has shown that about 5 to 15% of people ...