CIs revolutionized solid organ transplant immunosuppression ... target is identical -- calcineurin -- making CsA and TAC pro-drugs in the sense that they must bind to an intracellular intermediary ...

Drugs that induce liver enzyme systems ... corticosteroids have become persona non grata in immunosuppressive regimens. Over the past 20 years, an impressive body of research has been devoted ...

Multiple infections were common. The metabolic effects of the immunosuppressive drugs and corticosteroids received by these patients are discussed in relation to the high incidence of unusual ...

Research from Radboud university medical center reveals that T cells from the adaptive immune system can manipulate the memory of innate immune cells. Previously, it was believed that the memory ...

Type 1 diabetes develops when the body destroys its own insulin-producing cells. Using stem cells to replace them could be a ...

For organ transplant recipients, understanding the relationship between their life-saving procedure and potential lymphoma ...