While the etiology of IPF is unknown, preventing injury/damage to the epithelium barrier and consequent expansion of fibroblast and extracellular matrix is an appropriate step in the right direction.

The study examined one of these brakes, called MKP1—which the team found was expressed at lower levels in fibroblasts from ...

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease in ... express a receptor on their surface that promotes ...

with evidence of reduced expression among profibrotic proteins produced by basal-like cells and fibroblasts that contribute to the progression of IPF, including data from four biomarkers that were ...

with evidence of reduced expression among profibrotic proteins produced by basal-like cells and fibroblasts that contribute to the progression of IPF, including data from four biomarkers that were ...

Antifibrotic treatment rates for IPF differ significantly between referral hospitals and general hospitals or clinics, with higher rates in referral hospitals. Many patients with mild IPF remain ...

Generative AI played a crucial role in developing ISM001-055, targeting TNIK for IPF treatment. Future studies are needed to further explore ISM001-055's potential in preventing IPF progression ...

There is ample evidence to justify investigating ET-1 blockade as a therapeutic approach in IPF. Data From Animal Studies. Transgenic mice with lung-specific overexpression of the human gene for ...