To address this problem, antibody engineers introduced a serine-to-proline substitution that made the middle hinge region more like that found in IgG1 (ref. 7). This not only gave a more ...

biodegradable polymer at the hinge and near hinge regions of the therapeutic antibody trastuzumab effectively facilitated the brain delivery of this human monoclonal IgG1 antibody. Trastuzumab is ...

For outsourcing therapeutic antibody discovery ... mouse monoclonal antibodies comprising fully human Fab and upper hinge regions and mouse middle hinge and Fc regions. Optimized constant domains ...