Preventing HIV cell entry There is no cure for AIDS ... Currently, several antiviral drugs that target cellular receptors for HIV are also under investigation. For example, Tanox's (Houston ...

HIV-1 entry into cells is an attractive target for new antiviral agents. But will inhibitors aimed at the CCR5 co-receptor force HIV-1 to evolve more virulent forms? Other targets for entry ...

A dozen pharmaceutical companies, however, are developing drugs designed to block HIV's entrance into the white blood cell by creating a non-functional CCR-5 receptor. Already, some of them are in ...

At the cellular level, HIV-1 transmission involves a highly coordinated process whereby the virus binds to CD4 receptors and one of two coreceptors—CCR5 (R5) or CXCR4 (X4)—on host immune cells, ...

Coreceptors are responsible for a crucial step between Env binding to the receptor CD4 and membrane fusion mediated by the gp41 fusion peptide. Determinants of HIV cell tropism & chemokine ...

CCR5 is the most commonly used receptor by HIV-1 - the virus strain of HIV that dominates around the world - to enter cells. But a very small number of people who are resistant to HIV have two ...

This article explores the difficulties faced in attempting to treat HIV, an innovative prevention strategy and the ...

Am J Health Syst Pharm. 2009;66(8):715-726. Mechanism of action of maraviroc. Before fusion of the HIV viral envelope and host cell membrane can occur, an HIV glycoprotein complex consisting of ...