Conditional alleles may be given priority when knockout alleles ... at the gene expression level. Finally, we note that introducing experimental envirotypes into mouse phenotyping protocols ...

to knockout and characterize all protein-coding genes in the mouse genome. Knocking out the activity of a gene provides valuable clues about what that gene normally does. However, creating and ...

To create a knockout mouse, scientists genetically engineer the animal by disrupting a gene of interest. This may be done by deleting portions of the gene's DNA sequence to make it nonfunctional ...

One such gene is Astrotactin 2 (ASTN2 ... Hanzel spent two years creating a knockout mouse that lacked ASTN2, and then studied the brains and activity of both infant and adult mice.

The investigator will initiate a CRISPR-KI request in iLab. The request form requires the gene name and a brief allele description. An IACUC protocol number, mouse transfer information, and a charge ...

Researchers at Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas ...

Both gene knockout and knock-in models are powerful tools widely used in biomedical research to gain important insights into ...

A research group has discovered that in mammals, a protein kinase A (PKA) promotes wakefulness, while protein phosphatase 1 (PP1) and calcineurin promote sleep. This study revealed that the balance ...

Researchers have uncovered how loss of the MeCP2 protein triggers early molecular changes leading to Rett syndrome, a severe ...

The study is published in Nature. Focusing on PKA and dephosphorylation enzymes, the research group created comprehensive gene knockout mice and conducted further experiments inducing the ...

This fundamental study substantially advances our understanding of the role of zinc in metabolism, specifically a newly established clinical link between mutations in the zinc transporter SLC39A5, ...

While previous attempts have been made, in-depth phenotypic changes resulting from mitochondrial gene knockout ... within the cerebral cortex of these mice, accompanied by hippocampal atrophy ...