One such gene is Astrotactin 2 (ASTN2 ... Hanzel spent two years creating a knockout mouse that lacked ASTN2, and then studied the brains and activity of both infant and adult mice.

However, the molecular mechanisms involved in sleep regulation remain unclear. Professor Hiroki Ueda, Doctoral Student Yimeng ...

Researchers have developed a light-induced gene therapy that targets the mitochondria of cancer cells, triggering cell death.

A research group has discovered that in mammals, a protein kinase A (PKA) promotes wakefulness, while protein phosphatase 1 (PP1) and calcineurin promote sleep. This study revealed that the balance ...

the team introduced choanoflagellate Sox genes into mouse cells, replacing the native Sox2 gene achieving reprogramming towards the pluripotent stem cell state. To validate the efficacy of these ...

Researchers have uncovered how loss of the MeCP2 protein triggers early molecular changes leading to Rett syndrome, a severe ...

A gene therapy based on an enhanced lipid nanoparticle (LNP) loaded with vascular endothelial growth factor (VEGF) mRNA could be developed for the treatment of preeclampsia, according to a study in ...

While previous attempts have been made, in-depth phenotypic changes resulting from mitochondrial gene knockout ... within the cerebral cortex of these mice, accompanied by hippocampal atrophy ...

Animal imaging studies also confirmed the effects of the gene therapy were limited to cancer tissue and were undetectable in normal tissue.