Fibrinogen, a natural blood protein, is well known for playing a key role in hemostasis, tissue repair and host defence against pathogens. What is less widely known is that fibrinogen in human ...

beginning with platelet aggregation and activation of the coagulation cascade, followed by the conversion of fibrinogen to fibrin, and concluding with clot degradation into fibrin fragments.

See Figure 1 for a depiction of normal hemostasis. The activation of the coagulation cascade yields thrombin that converts fibrinogen to fibrin; the stable fibrin clot being the final product of ...