Newly discovered estrogen receptor-dependent signaling pathways demonstrate that estrogen functions in the cytosol as well as in the nucleus. The classic estrogen receptor signaling pathway occurs ...

In ERα-knockout mice, estradiol-mediated prevention of streptozotocin-induced apoptosis was partially abolished—this finding indicates that ERα is not the only estrogen-signaling pathway in β ...

This two-pronged attack hits an essential signaling pathway that drives many breast cancers that are more resistant to ...