Post implantation, de novo methylation begins (red circles), mediated primarily by DNA (cytosine-5-)-methyltransferase-3alpha (DNMT3A) and -3beta (DNMT3B) (top). When methylation affects CpG ...
Targeted de novo methylation during development involves ... In animal cells, DNA can be modified by methylation of cytosine residues in CpG dinucleotides, and the N-terminal tails of histone ...
The latter is called an epigenetic alteration. While cytosine methylation is a healthy process, methylation of promoter CpG islands has also been shown to be a critical hallmark in many cancer cells.
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