Several cancer chemotherapy drugs work by producing excessive DNA damage that causes cell death directly or following DNA replication. Survival is promoted through repair of these lesions by a ...

How do we find out which protein works in a particular DNA repair pathway? We know that if a DNA repair gene is mutated, cells become more sensitive to DNA damaging agents. Researchers in the ...

Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous recombination is the exchange of ...

If DNA damage is not properly repaired, mutations can occur, which may result in diseases like cancer. Cells use repair systems to fix this damage, with specialized proteins locating and binding ...

DNA repair: A look inside the cell's 'repair café'. ScienceDaily . Retrieved November 23, 2024 from www.sciencedaily.com / releases / 2024 / 11 / 241121115648.htm ...

After all, the cell must repeat its whole genetic material, including billions of genetic letters, before it can divide. Read ...

Each cell in our body experiences up to tens of thousands of DNA-damaging events per day, primarily from routine cellular ...

But Storici's team found that RNA can also help cells repair a severe form of DNA damage called a double-strand break, or DSB. A DSB means both strands of the DNA helix have been severed.