DNA polymerases need a pre-existing DNA or RNA chain end (a primer) onto which to add each nucleotide. For this reason, the lagging strand polymerase requires the action of a DNA primase enzyme ...

As DNA polymerase makes its way down the unwound ... whereas the other is called the lagging strand. The leading strand is synthesized continuously, as shown in Figure 5. In contrast, the lagging ...

The process begins by unzipping DNA's ladder-like structure, resulting in two strands called the leading and lagging strands ... that forces the leading strand polymerase to let go of the new ...