Several cancer chemotherapy drugs work by producing excessive DNA damage that causes cell death directly or following DNA replication. Survival is promoted through repair of these lesions by a ...

"The nucleus isn't just a passive storage space for DNA; it has its own metabolic needs and processes." In the second study, ...

Cancer researchers at the University of Chicago and the University of California, San Francisco (UCSF) have discovered that mutations in certain genes can lead to the accumulation of DNA errors, ...

A new "toolkit" to repair damaged DNA that can lead to aging, cancer and motor neuron disease (MND) has been discovered by ...

Laboratory experiments with cancer cells reveal two ways in which tumors evade drugs designed to starve and kill them, a new study shows.

We provided the first conclusive evidence that the basic cause of cancer is damage to DNA. The discovery changed scientific opinion dramatically and marked a turning point for cancer research. Until ...

The team says the unprecedented amount of data allowed them to uncover new patterns in the DNA of cancer - hinting at causes that are not yet understood. They add that the genetic clues will ...

Those featured circles, ecDNAs, are small and often contain a few genes on their circular DNA. Frequently, these genes are cancer-associated genes called oncogenes. When a cancer cell contains ...

Great white sharks may hold the secrets to curing cancer and other age-related diseases, experts believe. The first map of great whites sharks' DNA has revealed "mutations" that protect the ...

A team of researchers led by Stanford University and San Diego-based Boundless Bio have identified an oral small molecule that specifically targets extrachromosomal DNA (ecDNA) in cancer cells ...