Cytosine methylation of CpG dinucleotide ... one carbon metabolism provides the methyl groups for all biologic methylation reactions that in turn is dependent on methyl donors (methionine and ...

such as coding for proteins (mRNA), transferring amino acids (tRNA), and catalyzing biochemical reactions (ribozymes). Cytosine can undergo chemical modifications that play crucial roles in gene ...

The crucial nature of the contacts between cytosine methyl groups and the protein is underscored by mutational analysis; mutation of residues contacting either methyl group results in a ...

Researchers can build models to predict gene expression by detecting and differentiating between cytosine methylation and hydroxymethylation marks in the genome. DNA methylation is an epigenetic ...

The aromatic rings in guanine's structure make it a relatively stable molecule, but it can still undergo various chemical reactions, such as oxidation, reduction, and methylation. One of the most ...

Study: CpGPT: a Foundation Model for DNA Methylation. Image Credit: Shutterstock AI In a recent pre-print* study posted to the bioRxiv server, a team of researchers introduced the Cytosine ...