AEDs that induce the CYTOCHROME P450 ENZYME SYSTEM. Cytochrome P450 enzyme-inducing AEDs, including phenobarbital, primidone, phenytoin, carbamazepine and, to a lesser extent, oxcarbazepine and ...
will be associated with less therapeutic variability than warfarin because its structure precludes it from being metabolized by the cytochrome P450 (CYP450) system. By contrast, warfarin is ...
Changes Clinical Practice Breast cancer patients who are taking tamoxifen and who require an antidepressant should be given antidepressants which do not inhibit the enzyme cytochrome P450 2D6 ...
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