Macrophages emerged as the most abundant immune ... A key finding of this research is the upregulation of CXCR4 in myeloid cell clusters within failing hearts compared to those in normal hearts.

The cytokine macrophage migration inhibitory factor ... have identified MIF as a ligand for the CXC-chemokine receptors CXCR2 and CXCR4, and suggest that targeting MIF could be used as an ...