These factors form two cascades known as the intrinsic and extrinsic coagulation pathways. Both of these ... VIIa to initiate the plasma coagulation cascade. The TF and factor VIIa complex ...

See Figure 1 for a depiction of normal hemostasis. The activation of the coagulation cascade yields thrombin that converts fibrinogen to fibrin; the stable fibrin clot being the final product of ...