More importantly, experiments reported to date have only established a correlation, not a causal relationship, between protein localization and Hh-pathway activity. Cilia-dependent and independent ...

Several components of the hedgehog (Hh) pathway are crucial to basal cell carcinoma (BCC) tumorigenesis. Primary cilia have emerged as key organelles in Hh signal transduction in mammalian systems ...

Several components of the hedgehog (Hh) pathway are crucial to basal cell carcinoma (BCC) tumorigenesis. Primary cilia have emerged as key organelles in Hh signal transduction in mammalian systems ...

primary cilia can simultaneously support major IFT functions of the cell (Figure 3). The primary cilium has gone from being an oddity, with no known function, to an organelle that is at the center ...