Chromatin insulators seem to control ... which then help initiate transcription of the RNA at the promoter. Enhancers accomplish this independently of their distance and location with respect ...

In a related vein, enhancers that regulate distal ... rather the act of transcription (and associated chromatin modifications), or if the RNA is the byproduct of a nearby enhancer that controls ...

Transcription activation of genes by estrogens is driven by enhancers, which are often located within the same Topologically Associating Domain (TAD) as non-targeted promoters. We investigated how ...

Neurobiology, Neurodegeneration and Repair Laboratory, National Eye Institute, National Institutes of Health, Bethesda, United States This important study employed multiple orthogonal techniques and ...

Cell-free DNA can be used for non-invasive cancer detection and disease monitoring to enhance personalized medicine.

In a complex called chromatin, long strands of DNA in cells ... Noncoding stretches of DNA, called enhancers, which regulate the spatiotemporal expression of other genes, play a pivotal role.

Specifically: Genome-wide detection of 5-hydroxymethylcytosine revealed active demethylation begins ahead of chromatin and transcription factor activity, while enhancer hypomethylation persists long ...