Scenarios in which ER stress contributes to disease are outlined and prospects for drug discovery are discussed. Among the cell death mechanisms addressed are: pro-apoptotic signals resulting from ...

including the stress that arises from the accumulation of unfolded proteins within a cell's endoplasmic reticulum (ER). To counterbalance this type of ER stress, higher eukaryotic cells possess a ...

two types of cell stress have previously been implicated in the development of type 2 diabetes. Endoplasmic reticulum (ER) ...

It is upregulated in cells that actively secrete proteins, and in various situations where protein aggregates accumulate in the endoplasmic reticulum (ER), causing ER stress. The exact mechanism of ...

Pancreatic cells, like human cells, have a limit to how much stress they can handle before they start to break down. Through ...

Inside cells, there exists an extensive system of canals known as the endoplasmic reticulum (ER), which consists of membrane-encased tubes that are partially broken down as needed—for instance ...

Enhanced FIB-SEM images of untreated cells and cells treated with Torin, which causes nutrient stress. The ER exit sites (magenta), ER (blue), and all lysosome-related organelles (cyan ...