These signalling systems operate beyond cell ... Figure 3: Cancer therapeutics that target components of the canonical Wnt pathway. Recent studies suggest that so-called cancer stem cells, which ...

Researchers from Tel Aviv Sourasky Medical Center presented data from a study that aimed to investigate the genetic mechanisms underlying yellow nail syndrome (YNS), a rare disorder characterized by ...

Frizzled (FZD) proteins are the principal receptors of the Wnt signaling pathway. However, whether Wnt ligands induce FZD endocytosis and degradation remains elusive. The transmembrane E3 ubiquitin ...

Cell signaling is also pivotal for multi-cellular ... their identification of a novel small molecule agonist of the canonical Wnt pathway and its use in modulation of MSC differentiation; and ...