The level of CYP3A4 expression may determine which patients best respond to certain drugs, and which patients experience side effects or even toxicity when the same dosage is administered.
[12] The induction of CYP3A4 might increase the metabolism of estradiols and other corticosteroids that are substrates of the isoenzyme. Women who take St. John's wort concurrently with oral ...
Substrates identified for CYP2J2 are also metabolized by CYP3A4. Extracted ion chromatograms of metabolites observed for albendazole, amiodarone, astemizole, thioridazine, mesoridazine ...
May potentiate cyclosporine. May antagonize anticoagulants (monitor), isoniazid, other CYP3A4 substrates (eg, indinavir, erythromycin). Increased risk of arrhythmias with digitalis. May need to ...
May potentiate cyclosporine (seizure risk). May antagonize anticoagulants (monitor), isoniazid, other CYP3A4 substrates (eg, indinavir, erythromycin). Increased risk of arrhythmias with digitalis.
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