The level of CYP3A4 expression may determine which patients best respond to certain drugs, and which patients experience side effects or even toxicity when the same dosage is administered.

Substrates identified for CYP2J2 are also metabolized by CYP3A4. Extracted ion chromatograms of metabolites observed for albendazole, amiodarone, astemizole, thioridazine, mesoridazine ...

For example, p-glycoprotein shares several substrates with CYP3A4, including several statins. While, p-glycoprotein does not contribute to the bioelimination of pitavastatin, it is (as discussed ...

May potentiate cyclosporine. May antagonize anticoagulants (monitor), isoniazid, other CYP3A4 substrates (eg, indinavir, erythromycin). Increased risk of arrhythmias with digitalis. May need to ...

May potentiate cyclosporine (seizure risk). May antagonize anticoagulants (monitor), isoniazid, other CYP3A4 substrates (eg, indinavir, erythromycin). Increased risk of arrhythmias with digitalis.