Through fluorescent labeling of the mouse plasma proteome, scientists led by Tony Wyss-Coray at Stanford University, California, found that certain subsets of microglia readily internalize plasma ...

Microglia cells (red) play an important role in the pathogenesis of Alzheimer's disease. Microglia are specialised macrophages that restrain the accumulation of ...

Alector Therapeutics, working with AbbVie, was testing whether modulating immune cells in brain would slow Alzheimer's ...

The scientists next explored how lysosomal function influenced the development of ApoE aggregates within microglia. Both in a cultured microglial cell line and in human iPSC-derived microglia, the ...

The brain contains many cell types, from the prominent neurons to the lesser-known microglia. The latter are integral to the ...

Scientists from CAS and BGI Research found that immunoglobulins are both drivers and markers of aging, with IgG accumulation ...

Alector is kicking off a resource realignment effort that will include a workforce reduction of around 17%. The biotech ...

Researchers mapped aging across multiple organs, finding immunoglobulin G accumulation drives aging by increasing structural ...