Medically reviewed by Daniel Combs, MD Benadryl (diphenhydramine) is an over-the-counter (OTC) antihistamine commonly used to treat allergies that is also sometimes used as a sleep aid for insomnia.

Why Do You Need Benadryl for Dogs? Dogs are curious and energetic, so it’s inevitable that some of them will wind up in some sticky situations. From running through some poison ivy to getting ...

Even common over-the-counter (OTC) medicines don't always play nicely with one another after they enter your system. However, some OTC drugs can be safely combined, including Benadryl and ibuprofen.