新研究表明在HER2阳性乳腺癌患者中，胚系BRCA1/2突变的发生率为6.6%，且不影响生存结果。乳腺癌是女性最常见的恶性肿瘤，遗传易感性作为其主要风险因素，在全部乳腺癌病例中占比达5%-10%。其中，约50%的病例与乳腺癌相关基因BRCA1和BRC ...

Figure 1: Deletion of exon 11 of Brca1 from mouse germ line. Figure 4: Effects of Brca1-Δ11 mutation on gene expression, tumorigenesis, cell survival and proliferation, and G 1 –S cell cycle ...

成都中医肿瘤研究院王剑峰主任认为，在治疗乳腺肿瘤的过程中，中医展现出了全方位的优势。他认为，中医不仅仅关注肿瘤本身，还注重整体调理，通过辨证施治，能够有效地缓解患者的症状，提高生活质量。中医通过多种手段，能够调节患者的免疫系统，增强机体的抗病能力，从 ...

【导读】BRCA1相关蛋白1(BAP1)作为一种肿瘤抑制因子，可以通过多种途径影响细胞周期、肿瘤免疫和细胞代谢。11月26日，上海交通大学研究团队在期刊《Cell Death Discovery》上发表了题为“BAP1 inactivation ...

The product of a sixth, newly-cloned FA-associated gene has been linked to BRCA1, and may finally offer some insight into the mechanism by which FA increases cancer susceptibility. You have full ...

In recent years, her focus has shifted to oncology, where she has become a trusted voice in understanding genetic risks for ...

People inherit two copies of each gene—one from each parent—an evolutionary fail-safe to ensure survival even when one of them doesn't function. For cancer-suppressor genes like BRCA1 ...

Having a mutated BRCA1 gene can mean a death sentence for those affected. Those with the faulty gene have up to an 87% lifetime risk of developing breast cancer and up to a 60% lifetime risk of ...

Those born with impaired BRCA1 and BRCA2 genes have a greater risk of developing breast, ovarian, prostate or pancreatic cancer. The NHS England screening programme is part of a drive to detect ...

How Libby Margolin turned her BRCA diagnosis into advocacy for genetic testing and PGD.

Breast cancer cells (green) invading through a layer of fibroblasts (red). Credit: Luke Henry, ICR. Many more people with breast cancer could get tested for mutations in the BRCA1 and BRCA2 genes ...

Some people with BRCA mutations can be closely monitored or choose to take preventative measures, such as actress Angelina Jolie. BRCA1 and BRAC2 are genes that we all carry. These genes normally ...