T cell lineage maturation is a highly regulated process requiring intact DNA repair capacity 1,2. BRCA1 (breast cancer 1, early onset) is a tumor suppressor that probably has a DNA repair function.

Figure 4: Effects of Brca1-Δ11 mutation on gene expression, tumorigenesis, cell survival and proliferation, and G 1 –S cell cycle checkpoint. We plated MEFs derived from E14.5 embryos at a ...