No writing assistance was utilized in the production of this manuscript. BRAF, a member of a serine/threonine kinase protein family, serves as an immediate downstream effector of RAS in the MAPK ...

人KRAS/NRAS/BRAF/PIK3CA基因突变联合检测试剂盒的IVDD（体外诊断医疗器械指令）办理是一个复杂且需严格遵循相关法规的过程。不过，值得注意的是，IVDD指令现已更新为IVDR（体外诊断医疗器械法规），并于2022年5月26日正式实施 ...

引言结直肠癌（CRC）易发生肝转移，初始不可切除结直肠癌肝转移（CRLM）是临床处理中的难点。目前多项指南共识对 CRLM 的治疗做出推荐，同时临床研究结果的出炉也带来更多证据。2024 年 11 月，CAIRO5 研究事后分析结果公布[1]，为 ...

colorectal (colon) cancer; epidermal growth factor receptor (EGFR); RAS; liquid biopsy; rechallenge; cetuximab; RAS; ...

Novartis' two-drug regimen of Tafinlar and Mekinist has been approved by the FDA as the first therapy for solid tumours that have a BRAF V600E mutation – regardless of where they occur in the body.

We played a major role in characterising the BRAF gene and its role in cancer, increasing our understanding of malignant melanoma. Our work on the gene and the structure of the BRAF protein ...